2. Signaling Pathways
  3. Epigenetics
  4. Histone Methyltransferase
  5. Histone Methyltransferase Chemical

Histone Methyltransferase Chemical

Histone Methyltransferase Isoform Comparison

Histone Methyltransferase Chemicals (2):

Cat. No. Product Name Effect Purity
  • HY-145103
    UNC6934
    		Chemical 99.15%
    UNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization.
  • HY-155817
    UNC7096
    		Chemical
    UNC7096 (compound 53) is a biotinylated affinity reagent. The phenyl ring of UNC7096 replaces the pyrimidine ring in UNC6934 (HY-145103) and introduces biotin at the para position of the phenyl ring, which has a high binding affinity to the NSD2-PWWP1 domain (Kd=46 nM). UNC7096 blocks the interaction between NSD2-PWWP1 and nucleosomal H3K36me2 by occupying the methyl-lysine binding pocket of NSD2-PWWP1. This binding is achieved by covalent binding through the formation of hydrogen bonds and a specific aromatic cage structure. UNC7096 can be used to capture proteins that interact with the NSD2-PWWP1 domain to further analyze the biological significance of these interactions.